Approaches to improve the pharmacokinetics of radiolabeled GLP-1 receptor ligands using antagonistic tracers
نویسندگان
چکیده
receptor ligands using antagonistic tracers Svetlana N. Rylova1,2,3, Beatrice Waser4, Luigi Del Pozzo 1,2,3, Roswitha Tönnesmann2, Rosalba Mansi2, Philipp T. Meyer2, Jean Claude Reubi4, Helmut R. Maecke,2 1 German Cancer Consortium (DKTK), Heidelberg, Germany 2 Department of Nuclear Medicine, University Hospital Freiburg, Freiburg, Germany 3 German Cancer Research Center (DKFZ), Heidelberg, Germany 4 Institute of Pathology, University of Berne, Berne, Switzerland
منابع مشابه
Approaches to Improve the Pharmacokinetics of Radiolabeled Glucagon-Like Peptide-1 Receptor Ligands Using Antagonistic Tracers.
UNLABELLED The glucagon-like peptide-1 (GLP-1) receptors are important biomarkers for imaging pancreatic β-cell mass and detection of benign insulinomas. Using GLP-1 receptor antagonists, we aimed to eliminate the insulin-related side effects reported for all GLP-1 receptor agonists. Additionally, using a nonresidualizing tracer, (125)I-Bolton-Hunter-Exendin(9-39)NH2 ((125)I-BH-Ex(9-39)NH2), we...
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تاریخ انتشار 2016